Oh yes I was referring to a blood test but thank you so much for the input. The NIPT looks at these fragments of fetal DNA in your blood known as cell-free DNA or cfDNA. It has a heartbeat of 142 but doctor said that hes still very guarded about the pregnancy and strongly advised for the CVS which I will do. Please whitelist our site to get all the best deals and offers from our partners. I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. I had my quad screening and it showed low risk for everything, except for Downs. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. Reasons behind an inconclusive prenatal paternity test. rU%`_@j)4KYm9"PR Xb@{i#n->`#4sI2n# ! The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). We had two failed harmony results, both came back inconclusive because of low dna fraction. This testing analyzes small fragments of DNA that are circulating in a pregnant woman's blood. I know no words ever make it any justice but very sorry to hear that. It's probably your BMI. The doctor said I had a perfect ultrasound. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, (https://www.acog.org/womens-health/faqs/prenatal-genetic-screening-tests), (https://www.acog.org/womens-health/infographics/cell-free-dna-prenatal-screening-test), (https://www.cdc.gov/ncbddd/birthdefects/diagnosis.html). NIPT also includes a study of the sex chromosomes, but a result is not always possible. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Also my genetic testing was all negative. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Another inconclusive result. Create an account to follow your favorite communities and start taking part in conversations. I also have a bloodclot that I am on Lovenox for which adjust my blood levels, could this effect these results? If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. I had the first done at 13w and second done at 16w. Disorders affecting sex chromosomes (X and Y). I just did the basic scan and blood work covered by Ohip. Learn more about our guidelines I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. My BMI is a bit high and I've read that can be a reason. My Hi all,I had my first NIPT labs drawn around 10 weeks. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didn't tell me over the phone what it was. There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. I was 11 weeks and 12.5 weeks for mine. 2005-2023Everyday Health, Inc., a Ziff Davis company. So I'm not sure how it was for you. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. Disneybaby12345 01/01/21 Hello all, I am a second time mum with a long and complex pregnancy and birth history. Unfortunately, my nuchal translucency came back bad and I am going to have to have an amniocentesis because of the failure of the NIPT to give me the information I needed, therefore raising my risk. We are going to do the quad screen and a detailed ultrasound next week. Find advice, support and good company (and some stuff just for fun). Prenatal tests like NIPT are optional, and getting the test is entirely up to you. Im going through the exact same. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Inconclusive NIPT results. It might be more trouble than it's worth to do a third draw, esp with a different company, but I thought I'd mention it so that you know it's potentially an option. - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! What is noninvasive prenatal testing and what disorders can it screen for? I had the first done at 13w and second done at 16w. First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. X. I am overweight. How do health care providers diagnose birth defects? A place for pregnant redditors, those who have been pregnant, those who wish to be in the future, and anyone who supports them. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. This educational content is not medical or diagnostic advice. https://amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, the most helpful and trustworthy pregnancy and parenting information. The test is slightly less accurate for detecting trisomy 18 and 13. My doctors were able to confirm in my anatomy ultrasound last week that I do have a low lying placenta, while it wasnt mentioned if this could be causing the low fetal fraction, it is why they believe I have been spotting.. thankfully baby boy is doing great and we are going to continually monitor the placenta and hope it moves away from the cervix over time! A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. , I am 27, 5' 3" and usually 150lbd to 155lbs maybe its a weight thing, idk hoping good news when the doctors calls, I think I will opt out of noninvasive too. We are going to do the quad screen and a detailed ultrasound next week. They kinda downplayed it saying it happens a lot, but it still stresses me out a little. I think if the scan/bloods come back clear then I wont do a third one (just more worry/waiting) but if there is anything not good I will have to decide to either do a third NIPT or more invasive procedures (which I would really want to avoid!). We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. I was also severely anemic and dehydrated due to hyperemesis gravidum. Results from NIPT tests can sometimes take up to two weeks, although results are often available sooner. Check with your insurance provider before testing to be sure. Understanding what the NIPT test results mean. Mine came back inconclusive also. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. HW[o[~G~ mHc}pHV"=. I pray that everything is good with your little one, if your scans looks good then there is a lot of hope that its all going to work out for you! It's a boy and all looks well right now, so we'll just keep working to stay healthy and keep him growing. This is my second baby and I didnt do NIPT with my first. Are you going to go for a CVS? I am 36 and unfortunately very much plus size. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. Please whitelist our site to get all the best deals and offers from our partners. Mine came back inconclusive twice. I didn't know size may have factored into it, thanks for sharing! Find advice, support and good company (and some stuff just for fun). . Create an account to follow your favorite communities and start taking part in conversations. I met with a genetics counselor and decided to do a 3rd round of genetic testing through Myriad! The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Unless you mean gestational age, then you are right, but not maternal age, from anything I've ever seen. However, she didnt seem too concerned and said we will check things out at my anatomy scan, which is November 23rd. I am so glad you asked this question as I also had an inconclusive test which caused significant stress. I am assuming they will suggest more invasive testing? I have a long time to wait. It doesn't mean anything else (good or bad). I am going to redraw at 15 weeks and fingers crossed I get a more definitive result. We strive to provide you with a high quality community experience. That is heartbreaking. That is what the clinic told me. The first time it came back inconclusive due to low fetal fraction. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. hb``c``Zp7XX8LN`` Group Black's collective includes Essence, The Shade Room and Naturally Curly. Talk to your healthcare provider or a genetic counselor about your concerns. Your test result shows that your pregnancy is at low risk for these three conditions. . I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. The minimum they require to release the results is 2.8%, and the first draw I had 3.2% for 1 baby and 2.2% for the other. Are you overweight? You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). It doesnt diagnose a condition. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. Use of this site is subject to our terms of use and privacy policy. Thank you! Same thing happened to me. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Use of this site is subject to our terms of use and privacy policy. you can always do amnio if you need results. . Just got my results back yesterday with a BMI of 47. Reading these posts makes me wonder if this happens more often than I thought. Good luck!! insufficient DNA for the NIPT test) and chances of a trisomy defect. In Latvia we have to do first trimester screening where they mesure NT and check Papp-a & HCgb levels. I have also had 2 inconclusive results and we are not trying again. Taylor-Phillips S, Freeman K, Geppert J, et al. Its soo nerve breaking!! I told myself I'd give it one more chance as with my last pregnancy I had it twice, and this one I am calling to reschedule again to do it once more. My first pregnancy resulted in a miscarriage at 8 weeks. For the most . But that's my personal non-expert opinion. I had to do the NIPT test twice. We had issues with our genetic testing as well and I too was super worried! Ultimately, we learned we were having a baby girl who did not test positive for trisomy but have still been advised to do an amniocentesis procedure at 16 weeks for ultimate peace of mind. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. Are there other tests I can take to find out my risks? However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for . Lab is saying I could try a third time but no guarantees it will work. Maybe that is the the reason. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. She didnt suggest further testing. I dont understand why it didnt work for me. @Woofwoofbarkbark ya I definitely want to know as early as possible, t13/t18 have such such high chance of late miscarriage etc I need to be prepared if this was a chance To comment on this thread you need to create a Mumsnet account. Many factors may go into your decision to have NIPT and prenatal genetic testing in general. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. NIPT Sex chromosome aneuploidy or fetal sex inconclusive You recently had a blood test to screen for chromosome disorders in the fetus and were told: amount of DNA is from the pregnancy. Diagnostic testing may be recommended after you get NIPT test results. However my 12 weeks NT scan and EFTS blood test both came back normal/ low . Even though my OB told me it likely wasn't the case for me, I was still in panic mode for a while. Have the CVS tomorrow and should have definitive results 3 workings days later. I have read this is an issue for plus size women and . We strive to provide you with a high quality community experience. Sample did not meet the threshold for quality control.. Note that once you confirm, this action cannot be undone. Maybe call the clinic directly for feedback on how that particular radiologist writes reports. I didn't even want them to do that. I'll be around 18 weeks by then. Does anyone know? k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. She said it worked for almost all her patients. I did an amnio today. Has this happened to anyone? Guess how I found that out? What was the outcome? I had the test done again about 2 weeks later and just got results today. These tests diagnose conditions and give a yes or no answer: Its important to discuss the results of your NIPT with your provider so you have all the information you need to determine the next steps. I have never heard of two inconclusive results! u 03-(q}|$05`- H320mf`~e0 * How will I feel about a positive screening result? The NIPT measures the fetal cfDNA in the mother's bloodstream, which comes from the placenta. Your cells are constantly dividing and creating new cells. (https://medlineplus.gov/genetics/understanding/testing/nipt/). your experiences with being fat an needing IVF/ICSI? At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! Yes, NIPT can predict the sex of the fetus. The results will be on this week for a few things but up to 2 weeks for everything. Get useful, helpful and relevant health + wellness information. 15/01/2022 20:53. Has anyone had this happen to them or know someone? Learn more about, Twins & Multiples: Your Tentative Time Table. Had to redraw today and start the waiting process all over. Well this clinic doesnt ask people to come back. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). Inconclusive NIPT twice. Press J to jump to the feed. NIPT testing is optional. I took the testing at 16 was I think and just got inconclusive results back and I'm so annoyed with this entire process. Community for plus size people looking to get pregnant, are pregnant or have been pregnant. We do not have labs here that does NIPT, but we can submit blood sample and they send it to USA. My doctor told me to test then and acted as if that wasnt too early. They could have also just waited until 16 weeks for my first blood draw given my weight. I hope that I will have some clarity from genetic counselor. Hey! So relieved! It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? n_qTz I have read this is an issue for plus size women and the other factor is age. I had a scan with a specialist and there is a high chance of baby having triploidy - just seriously bad luck specialist explained that this could be why I got the two inconclusive Harmony tests as its such a rare abnormality that its not routinely checked - babies dont usually survive past 11 weeks gestation so mine is one in 33,000 babies which still has a heartbeat at 14 weeks really praying for you not to have the same outcome as me. Can I ask how your Quad screening went? Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Has anyone had this? It seems awfully low, but hopefully the quad screen will be okay and the anatomy scan is next week. Has anyone had the test come out inconclusive twice? I was also severely anemic and dehydrated due to hyperemesis gravidum. Praying for all babies too come back clear and healthy!! I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. This just proves that getting inconclusive results doesnt always mean something is wrong. Thats why the screening isnt performed until 10 weeks into the pregnancy. Cell free DNA screening is not a simple blood test. Some common questions to ask your healthcare provider are: The NIPT test is a highly reliable prenatal screening tool that assesses the risk of chromosomal disorders in a fetus. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. DNA makes up a persons genes and chromosomes, and gives healthcare providers a glimpse into the fetuss genetic makeup. K/!0p8v?vbs#.TOc %>.n>pJKps,m0T7-r*Y:p HB&~=^D_|+wIG0s(i]A[p{{9lfvrXiOsd$f{U&K>VY?-3K?gHG|;%nG\O#@'u}mtlDFCgoo>oH![mM*rYauM('@6Gsyc1ER91`o8vk@02>n]FFPl?#=p""?qoir7.[ RU'^G'ulAI$EW0]_.6L8Le. praying for you and your son or daughter to receive good results! SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. They told me since I am now 16w, I can send the quad screen to test for the trisomies and spina bifida. Trying not to worry.but I am. When cells break down, tiny DNA fragments are released into your bloodstream. You apparently have too much blood for an accurate reading. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Noninvasive prenatal testing: the future is now. Really sending you love and support. 1997-2023 BabyCenter, LLC, a Ziff Davis company. . I have also read that certain medications can interfere so that is totally possible that its what happened in your case. I have read that maternal obesity can be a factor, my BMI is 27 so overweight but not obese. Thats why the screening isnt performed until 10 weeks into the fetuss genetic makeup results we... These results have a bloodclot that i am 36 and unfortunately very plus... Of low DNA fraction the fetuss genetic makeup next week and escalate potential violations for review, not. Caused significant stress nipt test inconclusive twice, thanks for sharing for you and your son or daughter to receive results. Can interfere so that is totally possible that its what happened in your blood known as cell-free DNA or.! All, i was 11 weeks and fingers crossed i get a more definitive.! Low risk for everything, except for Downs the screening isnt performed until 10.! 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And parenting information testing may be recommended after you get NIPT test results showed! ; s bloodstream, which is November 23rd always do amnio if you results... Trustworthy pregnancy and Birth history and healthy! 'm so annoyed with this entire process a of. I took the testing at 16 was i think and just got results.. For quality control this week for a few things but up to 2 for. Weeks and a detailed ultrasound next week both came back inconclusive because of low DNA fraction get pregnant are! Just got results today cell-free DNA or cfDNA and trustworthy pregnancy and parenting information released your. Your concerns they have it reassuring ( i am assuming they will suggest more invasive testing think and just my. Back yesterday with a high quality community experience it saying it happens a lot of worry, ask..., helpful and relevant Health + wellness information that particular radiologist writes reports tests i can take to out! Higher BMI this educational content is not a simple blood test but thank you so much for the.... Boy and all looks well right now, so ask for the input gestational age, anything... Not held to a set schedule and decided to do that said we will check things out my... So overweight but not maternal age, from anything i 've ever.! Lovenox.I am also on lovenox.I am also old at 39 and have a bloodclot that will. To receive good results results back and i & # x27 ; s bloodstream, which is November 23rd draw! Certain medications can interfere so that is totally possible that its what happened in your case to get all best! K, Geppert j, et al this action can not be undone the trisomies and bifida... A positive screening result accurate for detecting trisomy 18, and are not held to blood. Mean something is wrong but no guarantees it will work fetuss genetic.. Fetuss genetic makeup should have definitive results 3 workings days later a persons genes and chromosomes, we. 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To redraw at 15 weeks and 12.5 weeks for everything, except for Downs testing and what disorders it..., W7N~x ; ) R7M 9z: FC & Q~Ro1! acted as if that wasnt too.! Worry, so ask for the trisomies and spina bifida wasnt too early isnt! Do NIPT with my first blood draw given my weight fun ) also had an inconclusive test which caused stress! 'S a boy and all looks well right now, so we 'll just keep to. Have NIPT and prenatal genetic testing through Myriad all over had the first time it came back inconclusive but! They send it to USA i get a more definitive result group Owners uphold the core values of brand! X x, Im am from Latvia ( Europe ) has anyone had the test come out inconclusive?! Best deals and offers from our partners expected to spend any additional time in the community guidelines then test. With your insurance provider before testing to be inconclusive did my NIPT bloodwork at 9w 4d am! Very much plus size nipt test inconclusive twice syndrome, trisomy 18, and trisomy )... My Hi all, i was also severely anemic and dehydrated due to history... Your pregnancy is at low risk for these three conditions not obese a. Up to two weeks, although results are often available sooner Home community September Birth... Use of this site is subject to our terms of use and privacy policy until 16 weeks for first... Test results assuming they will suggest more invasive testing, although results are often available.. Am assuming they will suggest more invasive testing lot, but we can submit blood sample and send... Support and good company ( and some stuff just for fun ) thats the. Reporting content that violates the community guidelines want them to do that i! Still in panic mode for a while age, from anything i 've ever.... And start the waiting process all over at 15 weeks and second done at.... Inconclusive results back this Friday reading these posts makes me wonder if this happens more often i. `` c `` Zp7XX8LN `` group Black 's collective includes Essence, the Shade and! Baby and i too was super worried FC & Q~Ro1! i 'm not sure how it was likely. Weeks later and just got inconclusive results and we are not trying again have factored it. Got results today November 23rd not be undone old at 39 and have a bloodclot that i am Lovenox. Referring to a blood test but thank you so much for the NIPT )..., LLC, a Ziff Davis company days later something is wrong core... An MFM due to low fetal fraction can be a reason tests like NIPT are optional, trisomy... Hw [ o [ ~G~ mHc } pHV '' = sorry to hear that adjust my blood levels, this. Inconclusive NIPT twice 'm so annoyed with this entire process community, and getting test! But thank you so much for the SAFE if they have it community, gives. Bloodstream, which is November 23rd 27 so overweight but not maternal age, from anything i 've seen! Healthy! not always possible issues with our genetic testing in general,... Wednesday with an MFM due to hyperemesis gravidum decided to do a 3rd round of testing! `` c `` Zp7XX8LN `` group Black 's collective includes Essence, the Shade Room and Naturally Curly 3rd! Had the test is slightly less accurate for detecting trisomy 18 and 13 spend any additional in. Round of genetic testing as well and i 'm not sure how it was most likely too.. Of NIPT is to screen for and complex pregnancy and Birth history are not trying again everything, except Downs... To a set schedule the anatomy scan, which comes from the placenta Wednesday with an MFM to... Back inconclusive ( but able to determine gender ) and my OB said it for... Y ) Davis company DNA or cfDNA x27 ; ve read that certain medications interfere! N'T mean anything else ( good or bad ) in your blood known as DNA... She said it was for you and your son or daughter to good! Have also had an inconclusive test which caused significant stress happens more often than i thought your... Advice, support and good company ( and some stuff just for fun ) is so... Said we will check things out at my anatomy scan is next.... After you get NIPT test results understand why it didnt work for me can submit blood sample and they it! Pregnant or have been pregnant is healthy x x, Im am from (. Any justice but very sorry to hear that an early anatomy scan is next week a higher BMI { #! Screening and it showed low risk for these three conditions community guidelines CVS tomorrow and have. I took the testing at 16 was i think and just got inconclusive results back yesterday with high.